Further notes about the morphostasis concept – split files

(28) The regulation of effector class

There has been considerable discussion on the regulation of effector class in immune responses. For example, what provokes Tc responses or Th1 responses or Th2 responses or T-reg responses etc.. This can be extended to IgM, IgG, IgA and IgE responses. The solution to this conundrum might be more easily appreciated if we remember that inflammation acquires a memory by enlisting the help of adaptive immune responses. Now, innate inflammation has many facets and many specialised cells are involved; there are dendritic cells, Langerhans cells, M1 and M2 macrophages, polymorphs, eosinophils, basophils to name a few. It might be that the innate response that is evoked provokes a corresponding effector-class-response that amplifies this innate pattern on any subsequent encounter with a similar provocation. Should this be a valid interpretation then it could greatly simplify the investigation and understanding of the regulation of effector class.