Further notes about the morphostasis concept
This "page" began as a chronological sequence of "Other Thoughts". However, now that it has grown so large, I have split each new "thought" into a separate file. These can still be viewed, unsplit, in the original file (html link).
- (01) A letter sent, 1st January 1997
- (02) General email letter to various immunologists, 18th May 1997
- (03) E-mail to someone, 3rd July 1997
- (04) Comment on a published article dismissing the danger hypothesis, 8th August 2000
- (05) Notes, 6th January 2000
- (06) Reply to Melvin Cohn (dated August 2003)
- (07) Comments on "danger" vs "stranger" theories of lymphocyte activation, 1st December 2003:
- (08) Marrow derived stem cells and cancers
- (09) Autophagy and defence
- (10) Cancer and morphostasis
- (11) More thoughts on the "battle" with micro-organisms
- (12) Here are some extra thoughts generated whilst reading current articles
- (13) The backdrop for morphostasis
- (14) The backdrop for self/non-self
- (15) Atherosclerosis
- (16) Assumed purpose of the adaptive immune system
- (17) Pathogen (Microbe) Associated Molecular Patterns (PAMPS or MAMPS)
- (18) Silent paradigm shifts
- (19) Leverage – as a verb
- (20) Oddments
- (21) "The role of the inflammatory response is to combat tissue injury and infection."
- (22) The origin (and "reason") for the emergence of the adaptive immune system
- (23) Evolution (and emergence)
- (24) Tolerance of gut microbes (nurturing? cultivation?)
- (25) Prelude to thymic tolerance (next section)
- (26) Thymic tolerance
- (27) Self/nonself discrimination
- (28) The regulation of effector class
- (29) Trying to usurp the hegemony of extant, perceived wisdom
- (30) Injury and infection
- (31) More on microbes and the immune system
- (32) Conception blinkers
- (33) Class control
- (34) Wound induced polyploidy
- (35) The immune (or morphostatic) system may have evolved from an allo–competetive system
- (36) Aging
- (37) Specific and non–specific pathogenic stimuli
- (38) Tissue homeostasis (summary)
- (39) "The origin of immunity is in the management of the microbiome"
- (40) More on "pathogens"
- (41) And still more on "pathogens"
- (42) More on perspective distortion
- (43) Most cancers are just 'bad luck'
- (44) Entropy, evolution and life
- (45) Direct "pathogen"/microbe killing by the adaptive immune system
- (46) Innate immune memory
- (47) Fibrotic repair.
- (48) Immature immune systems
- (49) What is the "immune system's" response to non-damaging micro-organisms?
- (50) Our immune system evolved to . . . .
- (51) "There is – arguably – no such thing as an immune system . . . .
- (52) Tunnelling nanotubes . . . .
- (53) Destruction/construction . . . .
- (54) Cancer therapy
- (55) Fresh thoughts about phylogenetic/ontogenetic roll-out of immune defences
- (56) Microphages
- (57) A burgeoning cascade of tautologies
- (58) The bias of expectation in experimental set-up
- (59) Histology and immune cells
- (60) Cell senescence, cell shutdown, corpse disposal and its extrapolations into individual and population aging.
- (61) Comments posted on Polly Matzinger's researchgate project
- (62) The mass action of popular belief
- (63) The bug hunting and killing delusion
- (64) Tissue homeostasis and inflammation - historical
- (65) Conceptions vs Preceptions
- (66) Inflammation is a vasculitis
- (67) Self and non-self
- (68) Is the major function of phagocytes the disposal of microbes and other foreign agents?
- (69) Self? Or common encounters? Non-self? Or unusual encounters?
- (70) IHow can we break the hegemony of this preceived, majority view that the "purpose" of the adaptive immune system is to eliminate "non-self"?
- (71) Not seeing the wood for the trees.
- (72) Metchnikoff's prescience
- (73) Methuselah presentation on the emergence of concept in immunology
- (74) Good imagery (good metaphors)
- (~~) More to follow ......?
