"Morphostasis and Immunity”
This page includes a brief synopsis of this article, published in 1995
Here are the links to a reproduction of the article:
Synopsis and main points
- Morphostasis (tissue homeostasis) is discussed.
- Morphostasis must encompass:
- Intracellular and molecular biology
- Cell–to–cell communication and co–operation (gap junctions in particular)
- Within the embryo
- Development from zygote to mature animal
- Evolution from simple metazoans to mammals
- The general scheme of morphostasis including:-
- The surveillance for sick cells
- Cell and animal senescence
- The changing susceptibility to various diseases with ageing
- The renewal of sick cells and tissues
- Basic pathological mechanisms
- Immune ontogeny
- Immune phylogeny (from simple metazoans to mammals)
- It should also highlight how metazoan homeostasis and defence diverged as plants split from animals.
- It outlines the importance of the "zygote derived colony"
- It introduces the concept of healthy–self–cells and other–than–healthy–self–cells and their discrimination
- It explores the role of gap junctions in healthy-self expression
- It explores internal cell surveillance, apoptosis, necrosis and inflammation
- It explores the (probable) step by step evolution or morphostasis
- It introduces the concept of evolutionary shells
- It explores the pivotal role of natural killer cells in the switch to an anamnestic (memorising) immune process.
- It explores the "clinical consequences" of these points.
- "The general principles of morphostasis are discussed. I have made a committed assumption that gap junctions are the most important intracellular junctions (ICJs) in maintaining healthy self identity. Other ICJs may contribute a larger part than I have credited here. This idea has been constructed using a cycle of speculative hypothesis followed by falsification leading to new hypothesis. By experience, many of its more precise conclusions will prove to be not quite as conceived but they will prove to be closer than the current paradigm permits. If well founded, the hypothesis should prove to be a useful framework for a more focused investigation of the biochemical processes of morphostasis."
- I have put B-cells