Theories and the integrative function
Abstract: In recent years, dendritic cells have been placed centrally in starting and shaping the immune response, and a number of complex theories have been proposed to explain the immune response to antigen. Here, Zlatko Dembic overviews the Danger, Stranger and Integrity theories among others, and provides a broad look at early immune responses.
(Note: the original web site of this Journal - The Immunologist - has been withdrawn. Despite a promise that the journal was due to be relaunched and subscriptions carried over at this time, this journal has disappeared from view. Hogrefe and Huber were the original publishers.)
I have added a link to the British Library who will provide a copy of this article, but at cost. It might be worth approaching the author direct (Zlatko Dembic). I have a copy.
Google Scholar citation pages for Zlako Dembic. This site lists his other work and these, below, are the ones about "integrity".
- "Response to Cohn: The immune system rejects the harmful, protects the useful and neglects the rest of microorganisms"
- "On recognizing 'shades-of-gray' (self-nonself discrimination) or 'colour' (Integrity model) by the immune system
- "Beginning of the end of (understanding) the immune response
- "On integrity in immunity during ontogeny or how thymic regulatory T cells work
- "Immune system protects integrity of tissues
- "Do we need integrity?
- "Defending and integrating an organism by the immune system